Motif ID: SOX{8,9,10}.p2

Z-value: 2.062


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_367104840.572.0e-02Click!
SOX9chr17_+_676287630.312.4e-01Click!
SOX8chr16_+_9720640.292.8e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_128883125 6.222 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_-_7991992 4.023 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr7_-_27171600 3.622 HOXA9
homeobox A9
chr7_-_27171673 3.518 NM_152739
HOXA9
homeobox A9
chr7_-_27171648 3.375 HOXA9
homeobox A9
chr6_+_114285209 3.375 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr12_-_6103945 3.364 NM_000552
VWF
von Willebrand factor
chr1_-_197173159 3.358 LOC100131234
familial acute myelogenous leukemia related factor
chr5_-_16989371 3.225 NM_012334
MYO10
myosin X
chr5_-_16989290 3.203 MYO10
myosin X
chr1_-_95165037 2.948 CNN3
calponin 3, acidic
chr6_-_11340869 2.865 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_148705421 2.851 NM_015278
SASH1
SAM and SH3 domain containing 1
chr2_+_101680594 2.824 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr6_-_11340886 2.755 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340887 2.717 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_+_195336625 2.665 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_85066265 2.656 FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_101488380 2.625 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_189354510 2.623 LOC339929
hypothetical LOC339929
chr1_-_94475504 2.536 ARHGAP29
Rho GTPase activating protein 29
chr2_-_151052391 2.444 NM_005168
RND3
Rho family GTPase 3
chr7_-_11838260 2.443 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr14_+_62740878 2.403 NM_020663
RHOJ
ras homolog gene family, member J
chr16_+_81218142 2.356 CDH13
cadherin 13, H-cadherin (heart)
chr17_-_76985538 2.336


chr14_+_23008723 2.331 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr1_-_85703198 2.321 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr14_+_85066207 2.315 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_15957832 2.233 NM_017556
FBLIM1
filamin binding LIM protein 1
chr16_+_81218074 2.225 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr9_+_123501186 2.221 DAB2IP
DAB2 interacting protein
chr7_-_27186400 2.169 NM_153715
HOXA10
homeobox A10
chr1_-_151848039 2.147 S100A16
S100 calcium binding protein A16
chr1_-_223907283 2.141 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr14_+_23008742 2.107 NGDN
neuroguidin, EIF4E binding protein
chr3_+_189354167 2.103 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_164300758 2.096 NM_018086
FIGN
fidgetin
chr3_-_150533948 2.083 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr21_+_17807167 2.059 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr1_-_95165089 2.041 NM_001839
CNN3
calponin 3, acidic
chr8_+_40130143 1.996 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr7_+_134114957 1.926 CALD1
caldesmon 1
chr10_+_104525877 1.917 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr7_+_134114912 1.896 CALD1
caldesmon 1
chr12_-_57600564 1.864 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_+_40715799 1.860 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr5_+_40715778 1.860 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr12_+_62524778 1.836 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr15_-_53822468 1.796 NM_173814
PRTG
protogenin
chr12_-_87498225 1.779 NM_000899
NM_003994
KITLG

KIT ligand

chr1_-_68470585 1.777 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr15_+_37660568 1.768 NM_003246
THBS1
thrombospondin 1
chr9_+_115303527 1.768 NM_130795
RGS3
regulator of G-protein signaling 3
chr6_-_72187168 1.758 C6orf155
chromosome 6 open reading frame 155
chr5_-_92942680 1.727 FLJ42709
hypothetical LOC441094
chr8_+_55533047 1.712 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr10_+_73393998 1.710 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr11_+_20005704 1.703 NAV2
neuron navigator 2
chr14_-_37795290 1.697 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr2_+_54536780 1.681 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_-_150578023 1.678 TM4SF1
transmembrane 4 L six family member 1
chr16_-_52877829 1.675 IRX3
iroquois homeobox 3
chr3_+_195336631 1.658 HES1
hairy and enhancer of split 1, (Drosophila)
chr4_-_186969041 1.622 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr14_-_37795001 1.620 CLEC14A
C-type lectin domain family 14, member A
chr10_+_71482542 1.618 H2AFY2
H2A histone family, member Y2
chr10_-_97311084 1.609 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr10_+_71482362 1.606 NM_018649
H2AFY2
H2A histone family, member Y2
chr1_-_177378801 1.587 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr2_-_239987629 1.571 HDAC4
histone deacetylase 4
chr2_+_152900076 1.569 FMNL2
formin-like 2
chr8_-_29262240 1.545 NM_057158
DUSP4
dual specificity phosphatase 4
chr14_-_92284626 1.542 NM_001008530
NM_005606
LGMN

legumain

chr5_-_50714836 1.541 LOC642366
hypothetical LOC642366
chrX_+_15428820 1.531 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr1_+_64012154 1.531 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr2_-_56266408 1.518 LOC100129434
hypothetical LOC100129434
chr9_+_27099138 1.501 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr10_-_123346148 1.467 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr7_-_107430566 1.449 NM_002291
LAMB1
laminin, beta 1
chr10_+_24795465 1.437 KIAA1217
KIAA1217
chr7_-_111633428 1.433 DOCK4
dedicator of cytokinesis 4
chr8_-_119192985 1.428 NM_000127
EXT1
exostosin 1
chr14_+_22375753 1.423 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr10_+_24795446 1.421 KIAA1217
KIAA1217
chr17_-_37196463 1.402 NM_002230
NM_021991
JUP

junction plakoglobin

chr1_+_207668787 1.402 NM_001104548
LOC642587
NPC-A-5
chr5_+_50714996 1.396 ISL1
ISL LIM homeobox 1
chr3_-_187309442 1.389 NM_004454
ETV5
ets variant 5
chr15_-_68781662 1.384 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr16_+_64958060 1.374 CDH5
cadherin 5, type 2 (vascular endothelium)
chr13_-_40138607 1.362 NM_002015
FOXO1
forkhead box O1
chr16_+_64958025 1.358 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr10_+_24538094 1.349 KIAA1217
KIAA1217
chr16_-_52877868 1.342 NM_024336
IRX3
iroquois homeobox 3
chr10_+_24537725 1.337 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr4_+_146623405 1.336 NM_001003688
SMAD1
SMAD family member 1
chr11_+_129496792 1.329 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_+_77005287 1.320 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr1_-_79244948 1.313 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr12_-_57600336 1.305 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_-_239987557 1.301 NM_006037
HDAC4
histone deacetylase 4
chr12_+_52665196 1.292 NM_017409
HOXC10
homeobox C10
chr19_-_63205948 1.291 ZNF606
zinc finger protein 606
chr7_-_5429702 1.284 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr2_-_128138435 1.280 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr16_+_64958086 1.275 CDH5
cadherin 5, type 2 (vascular endothelium)
chr7_+_121300394 1.274 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr9_-_74757735 1.272 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_-_204108151 1.269 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr15_+_83724743 1.262 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr5_-_125958503 1.260 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr20_+_29656744 1.258 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr6_+_17390273 1.257 NM_001143941
RBM24
RNA binding motif protein 24
chr1_+_93686154 1.244 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr1_+_176577228 1.240 NM_004841
RASAL2
RAS protein activator like 2
chr4_-_159312973 1.233 FAM198B
family with sequence similarity 198, member B
chr10_-_105835609 1.228 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr6_-_75972286 1.222 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr5_+_149960820 1.215 NM_001166208
SYNPO
synaptopodin
chr17_+_72795567 1.212 NM_001113492
SEPT9
septin 9
chr1_-_94475840 1.197 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr10_-_105835525 1.196 COL17A1
collagen, type XVII, alpha 1
chr8_+_70541631 1.194 SULF1
sulfatase 1
chr3_-_151171576 1.182 PFN2
profilin 2
chr5_-_146813343 1.181 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr14_+_22375747 1.165 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr3_+_190990142 1.142 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr2_-_175578156 1.132 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr20_-_49818306 1.131 NM_006045
ATP9A
ATPase, class II, type 9A
chr6_-_75972473 1.125 COL12A1
collagen, type XII, alpha 1
chr4_-_186969202 1.124 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr2_-_70329067 1.119 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr19_+_60543032 1.117 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr20_-_49818268 1.111 ATP9A
ATPase, class II, type 9A
chr1_+_199975674 1.101 NAV1
neuron navigator 1
chrX_+_67965517 1.079 NM_004429
EFNB1
ephrin-B1
chr1_-_6468108 1.069 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_43539239 1.068 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr12_-_51173238 1.067 NM_005554
KRT6A
keratin 6A
chr6_-_42218692 1.066 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr4_-_159313167 1.054 NM_016613
FAM198B
family with sequence similarity 198, member B
chr20_-_55718982 1.042 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr6_+_17390910 1.037 NM_153020
RBM24
RNA binding motif protein 24
chr9_-_73573121 1.029 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr5_+_178919298 1.024 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr18_+_3441589 1.020 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr11_-_88864061 1.018 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr7_+_116099648 1.011 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr2_-_45090025 1.010 NM_016932
SIX2
SIX homeobox 2
chr15_+_68971835 1.009 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr18_-_24011349 1.005 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_+_50714714 1.004 NM_002202
ISL1
ISL LIM homeobox 1
chr4_+_74491272 1.000 ALB
albumin
chr3_+_51397756 0.996 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr1_-_152431175 0.987 NM_152263
TPM3
tropomyosin 3
chr5_-_111121150 0.974 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr12_-_8706533 0.966 MFAP5
microfibrillar associated protein 5
chr6_+_30702586 0.963 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr12_-_94135154 0.957 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr12_+_94135645 0.955 NM_017599
VEZT
vezatin, adherens junctions transmembrane protein
chr17_-_71017509 0.954 NM_001142643
CASKIN2
CASK interacting protein 2
chr8_+_70541412 0.953 NM_001128204
NM_015170
SULF1

sulfatase 1

chr16_-_73842884 0.951 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr2_+_37425240 0.945 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chrX_-_106846253 0.945 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr6_-_2785682 0.939 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chrX_-_44945025 0.939 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr20_-_3696344 0.938 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr4_-_159313613 0.937 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr9_-_35101534 0.924 KIAA1539
KIAA1539
chr12_+_51730101 0.923 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_92944680 0.911 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chrX_-_37964924 0.909 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr7_+_2638156 0.905 TTYH3
tweety homolog 3 (Drosophila)
chr3_+_25444753 0.903 NM_016152
RARB
retinoic acid receptor, beta
chr5_-_171643399 0.901 NM_152277
UBTD2
ubiquitin domain containing 2
chr2_-_222145240 0.901 NM_004438
EPHA4
EPH receptor A4
chr9_+_96807107 0.899 C9orf3
chromosome 9 open reading frame 3
chr20_-_17459973 0.899 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr16_+_27468942 0.896 NM_015202
KIAA0556
KIAA0556
chr8_-_6407882 0.896 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr5_+_15553768 0.893 FBXL7
F-box and leucine-rich repeat protein 7
chr3_+_25444837 0.889 NM_000965
RARB
retinoic acid receptor, beta
chr18_+_18003401 0.883 NM_005257
GATA6
GATA binding protein 6
chr4_+_95898098 0.882 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_+_76418214 0.878 LOC728723
hypothetical LOC728723
chr6_+_121798443 0.878 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr13_-_109757442 0.877 NM_001845
COL4A1
collagen, type IV, alpha 1
chr6_+_7671267 0.877 BMP6
bone morphogenetic protein 6
chr5_-_171643247 0.872 UBTD2
ubiquitin domain containing 2
chr3_-_150422474 0.870 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_183970093 0.868 NM_031935
HMCN1
hemicentin 1
chr2_+_74539039 0.868 NM_012477
WBP1
WW domain binding protein 1
chr13_+_109757593 0.865 NM_001846
COL4A2
collagen, type IV, alpha 2
chr12_-_10142779 0.863 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr18_+_7936885 0.861 PTPRM
protein tyrosine phosphatase, receptor type, M
chr2_+_159021653 0.857 PKP4
plakophilin 4
chr11_+_131286513 0.856 NTM
neurotrimin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 2.15e-07 GO:0007275 multicellular organismal development
1.32 3.64e-07 GO:0032502 developmental process
1.32 2.32e-05 GO:0048856 anatomical structure development
1.33 5.22e-05 GO:0048731 system development
2.00 1.44e-04 GO:0007264 small GTPase mediated signal transduction
1.21 2.12e-04 GO:0032501 multicellular organismal process
1.16 6.73e-04 GO:0050789 regulation of biological process
1.14 1.26e-03 GO:0065007 biological regulation
1.16 1.29e-03 GO:0050794 regulation of cellular process
1.26 2.21e-03 GO:0016043 cellular component organization
1.42 2.77e-03 GO:0007399 nervous system development
1.24 7.87e-03 GO:0071840 cellular component organization or biogenesis
1.55 1.02e-02 GO:0051128 regulation of cellular component organization
1.32 1.32e-02 GO:0048869 cellular developmental process
1.39 1.32e-02 GO:0009653 anatomical structure morphogenesis
1.57 1.35e-02 GO:0007155 cell adhesion
1.57 1.35e-02 GO:0022610 biological adhesion
1.94 1.72e-02 GO:0030029 actin filament-based process
1.09 1.76e-02 GO:0009987 cellular process
1.31 3.41e-02 GO:0030154 cell differentiation
1.74 4.17e-02 GO:0007409 axonogenesis
1.97 4.62e-02 GO:0030036 actin cytoskeleton organization
1.26 4.86e-02 GO:0071842 cellular component organization at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.39 2.82e-04 GO:0070161 anchoring junction
1.39 7.45e-04 GO:0005856 cytoskeleton
1.66 9.02e-04 GO:0030054 cell junction
2.36 1.66e-03 GO:0005912 adherens junction
1.07 1.29e-02 GO:0005622 intracellular
2.44 1.45e-02 GO:0030055 cell-substrate junction
1.92 2.13e-02 GO:0016323 basolateral plasma membrane
1.80 2.40e-02 GO:0015629 actin cytoskeleton
2.44 3.03e-02 GO:0005925 focal adhesion
1.07 4.41e-02 GO:0044424 intracellular part
1.67 4.90e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.89e-06 GO:0005515 protein binding
1.09 1.13e-05 GO:0005488 binding
1.84 7.19e-03 GO:0003779 actin binding
1.63 8.22e-03 GO:0008092 cytoskeletal protein binding