Motif ID: SOX{8,9,10}.p2

Z-value: 2.062


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_367104840.572.0e-02Click!
SOX9chr17_+_676287630.312.4e-01Click!
SOX8chr16_+_9720640.292.8e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_128883125 6.222 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_-_7991992 4.023 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr7_-_27171600 3.622 HOXA9
homeobox A9
chr7_-_27171673 3.518 NM_152739
HOXA9
homeobox A9
chr7_-_27171648 3.375 HOXA9
homeobox A9
chr6_+_114285209 3.375 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr12_-_6103945 3.364 NM_000552
VWF
von Willebrand factor
chr1_-_197173159 3.358 LOC100131234
familial acute myelogenous leukemia related factor
chr5_-_16989371 3.225 NM_012334
MYO10
myosin X
chr5_-_16989290 3.203 MYO10
myosin X
chr1_-_95165037 2.948 CNN3
calponin 3, acidic
chr6_-_11340869 2.865 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_148705421 2.851 NM_015278
SASH1
SAM and SH3 domain containing 1
chr2_+_101680594 2.824 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr6_-_11340886 2.755 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11340887 2.717 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_+_195336625 2.665 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_85066265 2.656 FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_101488380 2.625 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_189354510 2.623 LOC339929
hypothetical LOC339929

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.00 1.44e-04 GO:0007264 small GTPase mediated signal transduction
1.97 4.62e-02 GO:0030036 actin cytoskeleton organization
1.94 1.72e-02 GO:0030029 actin filament-based process
1.74 4.17e-02 GO:0007409 axonogenesis
1.57 1.35e-02 GO:0007155 cell adhesion
1.57 1.35e-02 GO:0022610 biological adhesion
1.55 1.02e-02 GO:0051128 regulation of cellular component organization
1.42 2.77e-03 GO:0007399 nervous system development
1.39 1.32e-02 GO:0009653 anatomical structure morphogenesis
1.35 2.15e-07 GO:0007275 multicellular organismal development
1.33 5.22e-05 GO:0048731 system development
1.32 3.64e-07 GO:0032502 developmental process
1.32 2.32e-05 GO:0048856 anatomical structure development
1.32 1.32e-02 GO:0048869 cellular developmental process
1.31 3.41e-02 GO:0030154 cell differentiation
1.26 2.21e-03 GO:0016043 cellular component organization
1.26 4.86e-02 GO:0071842 cellular component organization at cellular level
1.24 7.87e-03 GO:0071840 cellular component organization or biogenesis
1.21 2.12e-04 GO:0032501 multicellular organismal process
1.16 6.73e-04 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.44 1.45e-02 GO:0030055 cell-substrate junction
2.44 3.03e-02 GO:0005925 focal adhesion
2.39 2.82e-04 GO:0070161 anchoring junction
2.36 1.66e-03 GO:0005912 adherens junction
1.92 2.13e-02 GO:0016323 basolateral plasma membrane
1.80 2.40e-02 GO:0015629 actin cytoskeleton
1.67 4.90e-02 GO:0031012 extracellular matrix
1.66 9.02e-04 GO:0030054 cell junction
1.39 7.45e-04 GO:0005856 cytoskeleton
1.07 1.29e-02 GO:0005622 intracellular
1.07 4.41e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.84 7.19e-03 GO:0003779 actin binding
1.63 8.22e-03 GO:0008092 cytoskeletal protein binding
1.18 1.89e-06 GO:0005515 protein binding
1.09 1.13e-05 GO:0005488 binding